SARS-CoV-2, a betacoronavirus, and the pathogen that causes COVID-19, has impacted the world in a variety of ways. Vaccines and other treatments have helped prevent and treat COVID-19. However, as with all viruses, SARS-CoV-2 will mutate, possibly resulting changes in transmissibility and different pathways the virus can be involved in. Investigating the protein-protein interactions between human proteins and various strains of SARS-CoV-2 proteins can give insight into common pathways the various strains are involved in.

The interactions are classified into two different groups based on the method of being predicted: interolog (using BLAST) and domain (using HMMER). This resulted in 178,713 interactions across 14 strains (including the original, reference). These interactions were also characterized with KEGG (pathway enrichment), Gene Ontology (GO enrichment), Subcellular Localization, and Tissue Expression.

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